Regulation of High Mobility Group Box 1 (HMGB1) protein from human microglial cells in response to thrombin

Cunningham, Margaret Rose (Principal Investigator)
Butler, Liam (Post Grad Student)

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Project: Research

Description

The aim of this project was to investigate HMGB1-mediated microglial cell activity in response to thrombin as a potential mechanism of inflammation.

Short title	Thrombin-mediated HMGB1 regulation
Status	Finished
Effective start/end date	1/10/18 → 31/08/19

Keywords

GPCRs
Thrombin
HMGB1
Microglia
Inflammation

1 Finished

Molecular mechanisms of HMGB1 release from platelets and its implication in chemotherapy-induced peripheral neuropathy and thrombosis
Domoto, R., Cunningham, M. R. & Kawabata, A.
1/09/19 → 31/08/20
Project: Research Fellowship