A multicentre point prevalence study of antibiotics utilization in hospitalized patients in an urban secondary and a tertiary healthcare facilities in Nigeria: findings and implications

Olayinka O. Ogunleye, Modupe R. Oyawole, Patricia T. Odunuga, Folasade Kalejaye, Adesola F. Yinka-Ogunleye, Adesola Olalekan, Sunday O. Ogundele, Bernard E. Ebruke, Atinuke Kalada Richard, Bene D Anand Paramadhas, Amanj Kurdi, Jacqueline Sneddon, Andrew Seaton, Brian Godman

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The understanding of antimicrobial utilization patterns is pertinent to successful implementation of the National Action Plans on Antimicrobial Resistance (AMR). There is, however, limited information on antibiotics utilization in Nigeria. This study was undertaken to build on existing information and provide direction for appropriate interventions including Antibiotics Stewardship Programs (ASP). Method: A Point Prevalence Study (PPS) was conducted in two public urban health facilities in Lagos, Nigeria using a design adapted from the European Center for Disease Prevention and Control (ECDC) and Global-PPS surveys. Results: The prevalence of antibiotics use was 80.6% administered mostly parenterally (83.1% of total prescriptions) with concerns with extended surgical antibiotics prophylaxis. The mostly used antibiotics in the secondary hospital were parenteral metronidazole (32.4%), ceftriaxone (27.5%), and amoxicillin + clavulanate (8.2%) while the mostly used in the tertiary hospital were ceftriaxone (25.3%), parenteral metronidazole (19.1%), and amoxicillin + clavulanate (9.3%). There was an appreciable lack of specific functional capacities, policies, and processes to promote appropriate antimicrobial use in both hospitals. Conclusions: There is high rate of antibiotics utilization in these facilities with lack of institutional frameworks and processes for ensuring appropriate antibiotic use. The study provides the information needed to improve future antimicrobial use in hospitals and reduce AMR.

Original languageEnglish
Number of pages32
JournalExpert Review of Anti-infective Therapy
Early online date21 Jun 2021
DOIs
Publication statusE-pub ahead of print - 21 Jun 2021

Keywords

  • multicentre
  • point prevalence study
  • antibiotics
  • hospitalized patients
  • urban
  • secondary and tertiary healthcare
  • Nigeria

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