A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62

I.B. McInnes, J.A. Gracie, B.P. Leung, M. Harnett, F.Y. Liew, W. Harnett

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Meeting abstract on a novel therapeutic approach to cytokine modulation in articular inflammation. Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.
Original languageEnglish
Number of pages1
Publication statusPublished - 2003
Event23rd European Workshop for Rheumatology Research - Marseille, France
Duration: 27 Mar 2003 → …


Conference23rd European Workshop for Rheumatology Research
CityMarseille, France
Period27/03/03 → …


  • cytokine modulation
  • physiology
  • immunology
  • articular inflammation

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