A public-private partnership to unlock the untargeted kinome

Stefan Knapp; Paulo Arruda; Julian Blagg; Stephen Burley; David Drewery; Aled Edwards; Doriano Fabbro; Paul Gillespie; Nathanael S Gray; Bernhard Kuster; Karen E  Lackey; Paulo Mazzafera; Nick Tomkinson; Timothy Willson; Paul Workman; William Zuercher

doi:10.1038/nchembio.1113

A public-private partnership to unlock the untargeted kinome

Stefan Knapp, Paulo Arruda, Julian Blagg, Stephen Burley, David Drewery, Aled Edwards, Doriano Fabbro, Paul Gillespie, Nathanael S Gray, Bernhard Kuster, Karen E Lackey, Paulo Mazzafera, Nick Tomkinson, Timothy Willson, Paul Workman, William Zuercher

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

Abstract

Chemical probes are urgently needed to functionally annotate hitherto untargeted kinases and stimulate new drug discovery efforts to address unmet medical need. The size of the human kinome combined with the high cost associated with probe generation severely limits access to new probes. We propose a large scale public-private partnership as a new approach which offers economies of scale, minimized redundancy, and sharing of risk and cost.

Original language	English
Pages (from-to)	3-6
Number of pages	4
Journal	Nature Chemical Biology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/nchembio.1113
Publication status	Published - Jan 2013

Keywords

public-private partnership
untargeted kinome
chemical biology

Access to Document

10.1038/nchembio.1113

Cite this

Knapp, Stefan ; Arruda, Paulo ; Blagg, Julian ; Burley, Stephen ; Drewery, David ; Edwards, Aled ; Fabbro, Doriano ; Gillespie, Paul ; Gray, Nathanael S ; Kuster, Bernhard ; Lackey, Karen E ; Mazzafera, Paulo ; Tomkinson, Nick ; Willson, Timothy ; Workman, Paul ; Zuercher, William. / A public-private partnership to unlock the untargeted kinome. In: Nature Chemical Biology. 2013 ; Vol. 9, No. 1. pp. 3-6.

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abstract = "Chemical probes are urgently needed to functionally annotate hitherto untargeted kinases and stimulate new drug discovery efforts to address unmet medical need. The size of the human kinome combined with the high cost associated with probe generation severely limits access to new probes. We propose a large scale public-private partnership as a new approach which offers economies of scale, minimized redundancy, and sharing of risk and cost.",

keywords = "public-private partnership, untargeted kinome, chemical biology",

author = "Stefan Knapp and Paulo Arruda and Julian Blagg and Stephen Burley and David Drewery and Aled Edwards and Doriano Fabbro and Paul Gillespie and Gray, {Nathanael S} and Bernhard Kuster and Lackey, {Karen E} and Paulo Mazzafera and Nick Tomkinson and Timothy Willson and Paul Workman and William Zuercher",

year = "2013",

month = jan,

doi = "10.1038/nchembio.1113",

language = "English",

volume = "9",

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journal = "Nature Chemical Biology",

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A public-private partnership to unlock the untargeted kinome. / Knapp, Stefan; Arruda, Paulo; Blagg, Julian; Burley, Stephen; Drewery, David; Edwards, Aled; Fabbro, Doriano; Gillespie, Paul; Gray, Nathanael S; Kuster, Bernhard; Lackey, Karen E ; Mazzafera, Paulo; Tomkinson, Nick; Willson, Timothy; Workman, Paul; Zuercher, William.

In: Nature Chemical Biology, Vol. 9, No. 1, 01.2013, p. 3-6.

Research output: Contribution to journal › Article › peer-review

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T1 - A public-private partnership to unlock the untargeted kinome

AU - Knapp, Stefan

AU - Arruda, Paulo

AU - Blagg, Julian

AU - Burley, Stephen

AU - Drewery, David

AU - Edwards, Aled

AU - Fabbro, Doriano

AU - Gillespie, Paul

AU - Gray, Nathanael S

AU - Kuster, Bernhard

AU - Lackey, Karen E

AU - Mazzafera, Paulo

AU - Tomkinson, Nick

AU - Willson, Timothy

AU - Workman, Paul

AU - Zuercher, William

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AB - Chemical probes are urgently needed to functionally annotate hitherto untargeted kinases and stimulate new drug discovery efforts to address unmet medical need. The size of the human kinome combined with the high cost associated with probe generation severely limits access to new probes. We propose a large scale public-private partnership as a new approach which offers economies of scale, minimized redundancy, and sharing of risk and cost.

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KW - untargeted kinome

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A public-private partnership to unlock the untargeted kinome

Abstract

Keywords

Access to Document

Other files and links

SMSdrug.net: Alignment Of Synthesis, Medicinal Chemistry And Strucrural Genomics To Accelerate Uk Drug Discovery: Network SMS-Drug

INNOVATIVE TARGETS FOR CIRCADIAN DRUG DISCOVERY: REV-ERBALPHA AND RORALPHA

SMSdrug quarterly meeting

The Untargeted Kinome

Cite this

A public-private partnership to unlock the untargeted kinome

Abstract

Keywords

Access to Document

Other files and links

Projects

SMSdrug.net: Alignment Of Synthesis, Medicinal Chemistry And Strucrural Genomics To Accelerate Uk Drug Discovery: Network SMS-Drug

INNOVATIVE TARGETS FOR CIRCADIAN DRUG DISCOVERY: REV-ERBALPHA AND RORALPHA

Activities

SMSdrug quarterly meeting

The Untargeted Kinome

Cite this