A traceless solid-phase synthesis of pteridines

C.L. Gibson; S. La Rosa; C.J. Suckling

doi:10.1016/S0040-4039(02)02782-X

A traceless solid-phase synthesis of pteridines

C.L. Gibson, S. La Rosa, C.J. Suckling

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The linking of pyrimidines to polystyrene supports via either a 2- or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.

Original language	English
Pages (from-to)	1267-1270
Number of pages	3
Journal	Tetrahedron Letters
Volume	44
Issue number	6
DOIs	https://doi.org/10.1016/S0040-4039(02)02782-X
Publication status	Published - 3 Feb 2003

Keywords

pyrimidines
polystyrene
oxidative cleavage

Access to Document

10.1016/S0040-4039(02)02782-X

Cite this

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title = "A traceless solid-phase synthesis of pteridines",

abstract = "The linking of pyrimidines to polystyrene supports via either a 2- or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.",

keywords = "pyrimidines, polystyrene, oxidative cleavage",

author = "C.L. Gibson and {La Rosa}, S. and C.J. Suckling",

year = "2003",

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T1 - A traceless solid-phase synthesis of pteridines

AU - Gibson, C.L.

AU - La Rosa, S.

AU - Suckling, C.J.

PY - 2003/2/3

Y1 - 2003/2/3

N2 - The linking of pyrimidines to polystyrene supports via either a 2- or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.

AB - The linking of pyrimidines to polystyrene supports via either a 2- or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.

KW - pyrimidines

KW - polystyrene

KW - oxidative cleavage

U2 - 10.1016/S0040-4039(02)02782-X

DO - 10.1016/S0040-4039(02)02782-X

M3 - Article

VL - 44

SP - 1267

EP - 1270

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 6

ER -