Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research

Stefan Senekowitsch, Philipp Schick, Bertil Abrahamsson, Patrick Augustijns, Thomas Gießmann, Hans Lennernäs, Christophe Matthys, Luca Marciani, Xavier Pepin, Alan Perkins, Maximilian Feldmüller, Sarah Sulaiman, Werner Weitschies, Clive G. Wilson, Maura Corsetti, Mirko Koziolek

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Abstract

Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation. Since many of these interactions are not fully understood, the COST action on “Understanding Gastrointestinal Absorption-related Processes (UNGAP)” was initiated in 2017, with the aim to improve the current comprehension of intestinal drug absorption and foster future developments in this field. In this regard, in vivo techniques used for the characterization of human GI physiology and the intraluminal behavior of orally administered dosage forms in the GI tract are fundamental to gaining deeper mechanistic understanding of the interplay between human GI physiology and drug product performance. In this review, the potential applications, advantages, and limitations of the most important in vivo techniques relevant to oral biopharmaceutics are presented from the perspectives of different research fields.
Original languageEnglish
Article number801
Number of pages36
JournalPharmaceutics
Volume14
Issue number4
DOIs
Publication statusPublished - 6 Apr 2022

Keywords

  • biopharmaceutics
  • imaging tools
  • in vivo
  • pharmacokinetics
  • aspiration
  • salivary tracer technique
  • magnetic marker monitoring
  • high-resolution manometry
  • telemetric capsules
  • scintigraphy
  • magnetic resonance imaging

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