Biocatalytic amide condensation and gelation controlled by light

Jugal Kishore Sahoo, Siva Krishna Mohan Nalluri, Nadeem Javid, Hannah Webb, Rein V. Ulijn

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30 Citations (Scopus)


We report on a supramolecular self-assembly system that displays coupled light switching, biocatalytic condensation/hydrolysis and gelation. The equilibrium state of this system can be regulated by light, favouring in situ formation, by protease catalysed peptide synthesis, of self-assembling trans- in ambient light; however, irradiation with UV light gives rise to the cis-isomer, which readily hydrolyzes to its amino acid derivatives (cis- + ) with consequent gel dissolution.

Original languageEnglish
Pages (from-to)5462-5464
Number of pages3
JournalChemical Communications
Issue number41
Publication statusPublished - 24 Apr 2014


  • peptides
  • gelation
  • gels
  • biocatalytic condensation

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