Cardiometabolic risk factor response to a lifestyle intervention: a randomized trial

Deirdre M. Harrington, Catherine M. Champagne, Stephanie T. Broyles, William D. Johnson, Catrine Tudor-Locke, Peter T. Katzmarzyk

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: Strategies to increase adherence to national dietary and physical activity (PA) guidelines to improve the health in regions such as the Lower Mississippi Delta (LMD) of the United States are needed. Here we explore the cardiometabolic responses to an education and behavior change intervention among overweight and obese adults that adapted the 2010 Dietary Guidelines (DG), with and without a PA component. Methods: White and African American overweight and obese adults were randomized to a DG group (n=61) or a DG+PA group (n=60). Both groups received a 12-week dietary education and behavior change intervention, and the DG+PA group also received a PA education and behavior change intervention with a pedometer. Changes in individual risk factors (blood pressure, fasting glucose, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol) and a continuous cardiometabolic risk score were determined. General linear models compared mean changes between groups, adjusting for covariates. Results: No main effect of intervention group was found in completers (n=99) and those who engaged with ≥80% of the intervention (n=83) for individual risk factors or the continuous risk score. Pooling both groups, those with higher baseline risk factor values realized greater improvements in individual risk factors. Conclusions: Adapting DG did not produce any cardiometabolic benefits, even with a PA component. Although the sample was ostensibly healthy, they were all overweight to mildly obese (body mass index of 25-34.9?kg/m2) and participants with higher baseline risk factor values showed more improvements. Adherence to longer-term behavior change may elicit changes in risk profile, so this should be explored. © Copyright 2015, Mary Ann Liebert, Inc. 2015.
Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalMetabolic Syndrome and Related Disorders
Issue number3
Early online date8 Jan 2015
Publication statusPublished - 20 Mar 2015


  • cholesterol
  • glucose
  • high density lipoprotein cholesterol
  • low density lipoprotein cholesterol
  • triacylglycerol
  • adult
  • weight reduction
  • behavior change
  • body height
  • body mass
  • body weight
  • cardiometabolic risk
  • cholesterol blood level
  • controlled study
  • diastolic blood pressure
  • female
  • follow up
  • glucose blood level
  • human
  • lifestyle
  • major clinical study
  • male
  • obesity
  • physical activity
  • priority journal
  • randomized controlled trial
  • risk factor
  • systolic blood pressure
  • triacylglycerol blood level
  • waist circumference
  • weight change
  • blood
  • cardiovascular diseases
  • diet
  • health behavior
  • low calory diet
  • middle aged
  • motor activity
  • overweight
  • treatment outcome
  • United States

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