Cobalt chromium (CoCr) alloy and stainless steel are widely used in orthopaedic implants. Cr(VI) is known to be released when metals corrode in vivo (Milošev et al., 2005) and may be toxic to local cells like osteoblasts and macrophages. Ning and Grant, 2000 J. Ning and M.H. Grant, Toxicol. In Vitro 14 (2000), pp. 329-335. Article | PDF (185 K)(25)Ning and Grant (2000) have demonstrated the acute toxicity of Cr(VI) to immortalised rat osteoblasts and shown the involvement of reduced glutathione (GSH) and glutathione reductase (GRd) in the interaction. This paper details the chronic toxicity of hexavalent chromium to U937 human monocyte cell lines.
|Publication status||Published - 2006|
|Event||BioScience 2006: Bioscience in the 21st Century - Glasgow, Scotland|
Duration: 23 Jul 2006 → 27 Jul 2006
|Conference||BioScience 2006: Bioscience in the 21st Century|
|Period||23/07/06 → 27/07/06|