Cooperative, ion-sensitive co-assembly of tripeptide hydrogels

Yousef M. Abul-Haija; Gary G. Scott; Jugal Kishore Sahoo; Tell Tuttle; Rein V. Ulijn

doi:10.1039/C7CC04796G

Cooperative, ion-sensitive co-assembly of tripeptide hydrogels

Yousef M. Abul-Haija, Gary G. Scott, Jugal Kishore Sahoo, Tell Tuttle, Rein V. Ulijn

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

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Abstract

Peptide co-assembly is of interest for the development of functional supramolecular biomaterials. Herein, computational simulations were combined with experimental validation to aid the design and understanding of cooporative co-assembly of a
structure-forming tripeptide (FFD) and a functional copper-binding tripeptide (GHK) leading to hydrogel formation in response to complexation with copper ions.

Original language	English
Pages (from-to)	9562-9565
Number of pages	4
Journal	Chemical Communications
Early online date	7 Aug 2017
DOIs	https://doi.org/10.1039/C7CC04796G
Publication status	E-pub ahead of print - 7 Aug 2017

Keywords

peptide co-assembly
functional supramolecular biomaterials
computational simulations
structure-forming tripeptide
copper-binding tripeptide
FFD
GHK
hydrogel formation
copper ions

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10.1039/C7CC04796GLicence: CC BY 3.0

Abul-Haija-etal-CC-2017-Cooperative-ion-sensitive-coassembly-of-tripeptide-hydrogelsFinal published version, 2.83 MBLicence: CC BY 3.0

1 Finished

E Infrastructure Bid - Capital Equipment Bid
Littlejohn, D., Fedorov, M., Mulheran, P. & Reese, J.
EPSRC (Engineering and Physical Sciences Research Council)
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Project: Research

Cite this

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doi = "10.1039/C7CC04796G",

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AU - Sahoo, Jugal Kishore

AU - Tuttle, Tell

AU - Ulijn, Rein V.

PY - 2017/8/7

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AB - Peptide co-assembly is of interest for the development of functional supramolecular biomaterials. Herein, computational simulations were combined with experimental validation to aid the design and understanding of cooporative co-assembly of astructure-forming tripeptide (FFD) and a functional copper-binding tripeptide (GHK) leading to hydrogel formation in response to complexation with copper ions.

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KW - functional supramolecular biomaterials

KW - computational simulations

KW - structure-forming tripeptide

KW - copper-binding tripeptide

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KW - GHK

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KW - copper ions

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Cooperative, ion-sensitive co-assembly of tripeptide hydrogels

Abstract

Keywords

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Projects

E Infrastructure Bid - Capital Equipment Bid

Cite this