Cytotoxic diterpenes from scoparia dulcis

M. Ahsan, S.N. Islam, A.I. Gray, W.H. Stimson

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Four new labdane-derived diterpenes, iso-dulcinol (1), 4-epi-scopadulcic acid B (2), dulcidiol (4), and scopanolal (5), together with two known diterpenes, dulcinol/scopadulciol (3) and scopadiol (6), were isolated from the aerial parts of Scoparia dulcis. The structures were determined by extensive NMR studies. The crude extracts as well as the pure diterpenes showed cytotoxicity against a panel of six human stomach cancer cell lines.
Original languageEnglish
Pages (from-to)958-961
Number of pages3
JournalJournal of Natural Products
Volume66
Issue number7
DOIs
Publication statusPublished - Jul 2003

Keywords

  • beta-glucuronidase inhibitor
  • cell-lines
  • acid-a
  • triterpenoids

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