Development of a solvent selection guide for aldehyde-based direct reductive amination processes

Fiona I. McGonagle, Donna S. MacMillan, Jane Murray, Helen F. Sneddon, Craig Jamieson, Allan J. B. Watson

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


A range of alternative, more environmentally conservative solvents have been evaluated for use within the direct reductive amination reactions of aldehydes using borane-based reductants. The data generated has been used to develop a guide to facilitate replacement of less desirable chlorinated solvents, such as DCE, from these widely used synthetic processes.

Original languageEnglish
Pages (from-to)1159-1165
Number of pages7
JournalGreen Chemistry
Issue number5
Early online date9 Apr 2013
Publication statusPublished - 1 May 2013


  • solvent selection
  • amination processes
  • borane-based reductants

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