Direct reductive aminations with catalytic molybdenum dioxide dichloride and phenylsilane

Clive A. Smith, Laura E. Cross, Kimberley Hughes, Rebecca E. Davis, Duncan B. Judd, Andrew T. Merritt

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24 Citations (Scopus)


A powerful direct reductive amination (DRA) method is developed, using catalytic MoO2Cl2 and phenylsilane (PhSiH3) as the reducing agent. The alkylation of a range of amines (pK(a) 0-7.8) with both an electron-deficient and two electron-rich-aldehydes is achieved in good to excellent yields. The novel employment of this DRA in alcoholic solvents significantly improves the reaction scope and excellent functional group selectivity is exhibited.
Original languageEnglish
Pages (from-to)4906-4911
Number of pages5
JournalTetrahedron Letters
Issue number34
Publication statusPublished - 26 Aug 2009


  • direct reductive amination (DRA)
  • molybdenum dioxide dichloride
  • phenylsilane
  • sodium triacetoxyborohydride
  • aryl PFP-sulfonate esters

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