Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein?

M D Houslay, A V Wallace, M E Cooper, Nigel Pyne, S R Wilson, C M Heyworth

Research output: Contribution to journalLiterature reviewpeer-review

6 Citations (Scopus)


One of the central features of insulin’s action on the liver is its ability to antagonize the actions of glucagon. Glucagon switches on glycogenolysis and gluconeogenesis in the liver by raising intracellular cyclic A M P concentrations through stimulating the activity of adenylate cyclase. Insulin would appear to achieve its antagonistic effect by causing a decrease in the intracellular concentrations of cyclic A M P .
Original languageEnglish
Pages (from-to)766-8
Number of pages3
JournalBiochemical Society Transactions
Issue number5
Publication statusPublished - 1984


  • 3',5'-cyclic-AMP phosphodiesterases
  • adenosine diphosphate ribose
  • adenosine triphosphate
  • adenylate cyclase
  • animals
  • cyclic AMP
  • enzyme activation
  • GTP-binding proteins
  • glucagon
  • guanosine triphosphate
  • Insulin

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