Dynamic combinatorial discovery of a [2]-catenane and its guest-induced conversion into a molecular square host

K.R. West, R.F. Ludlow, P.T. Corbett, P. Besenius, F.M. Mansfeld, P.A.G. Cormack, D.C. Sherrington, J.M. Goodman, Marc C.A. Stuart, Sijbren Otto

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)


A simple water-soluble naphthalenedithiol building block is converted quantitatively into a series of octameric [2]-catenanes, composed of two interlocked molecular squares. When this mixture is re-equilibrated in the presence of an adamantyl ammonium guest, the catenanes disassemble into their macrocyclic components that bind the guest with nanomolar affinity in water.
Original languageEnglish
Pages (from-to)10834–10835
Number of pages2
JournalJournal of the American Chemical Society
Issue number33
Publication statusPublished - 20 Aug 2008


  • molecular science
  • molecular squares
  • adamantyl ammonium

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