Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII

L Mooney; M Skinner; S. J. Coker; S. Currie

doi:10.1111/bph.13213

Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII

L Mooney, M Skinner, S. J. Coker, S. Currie

Strathclyde Institute Of Pharmacy And Biomedical Sciences

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Abstract

Calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is an important regulator of cardiac contractile function and dysfunction and may be an unwanted secondary target for anti-cancer drugs such as sunitinib and imatinib that have been reported to alter cardiac performance. This study aimed to determine whether anti-cancer kinase inhibitors may affect CaMKII activity and expression when administered in vivo.

Original language	English
Journal	British Journal of Pharmacology
Early online date	4 Jun 2015
DOIs	https://doi.org/10.1111/bph.13213
Publication status	Published - 2015

Keywords

cardiac contractility
calcium/calmodulin-dependent protein kinase II
imatinib
sunitinib
cardiotoxicity
phosphorylation

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10.1111/bph.13213

Mooney-etal-BJOP-2015-Effects-of-acute-and-chronic-sunitinib-treatment-on-cardiac-functionAccepted author manuscript, 857 KB

Susan Currie
- susan.currie@strath.ac.uk
- Strathclyde Institute Of Pharmacy And Biomedical Sciences - Reader
Person: Academic

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title = "Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII",

abstract = "Calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is an important regulator of cardiac contractile function and dysfunction and may be an unwanted secondary target for anti-cancer drugs such as sunitinib and imatinib that have been reported to alter cardiac performance. This study aimed to determine whether anti-cancer kinase inhibitors may affect CaMKII activity and expression when administered in vivo.",

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AU - Mooney, L

AU - Skinner, M

AU - Coker, S. J.

AU - Currie, S.

PY - 2015

Y1 - 2015

N2 - Calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is an important regulator of cardiac contractile function and dysfunction and may be an unwanted secondary target for anti-cancer drugs such as sunitinib and imatinib that have been reported to alter cardiac performance. This study aimed to determine whether anti-cancer kinase inhibitors may affect CaMKII activity and expression when administered in vivo.

AB - Calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is an important regulator of cardiac contractile function and dysfunction and may be an unwanted secondary target for anti-cancer drugs such as sunitinib and imatinib that have been reported to alter cardiac performance. This study aimed to determine whether anti-cancer kinase inhibitors may affect CaMKII activity and expression when administered in vivo.

KW - cardiac contractility

KW - calcium/calmodulin-dependent protein kinase II

KW - imatinib

KW - sunitinib

KW - cardiotoxicity

KW - phosphorylation

U2 - 10.1111/bph.13213

DO - 10.1111/bph.13213

M3 - Article

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

ER -

Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII

Abstract

Keywords

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Susan Currie

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