Enzyme-responsive polymer hydrogel particles for controlled release

Paul D. Thornton, Robert J. Mart, Rein V. Ulijn

Research output: Contribution to journalArticlepeer-review

221 Citations (Scopus)


A conceptually new approach to polymer-based enzyme-triggered release is described, whereby the selective catalytic action of (disease-specific) enzymes triggers a charge-induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).

Original languageEnglish
Pages (from-to)1252-1256
Number of pages6
JournalAdvanced Materials
Issue number9
Publication statusPublished - 7 May 2007


  • enzyme responsive
  • polymer hydrogel particles
  • controlled release
  • enzymes
  • hydrogels
  • biomaterials
  • biomedical applications
  • biomolecules
  • drug delivery

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