Evaluation of alternative solvents in common amide coupling reactions: replacement of dichloromethane and N,N-dimethylformamide

Donna MacMillan, J Murray, Helen F. Sneddon, Craig Jamieson, Allan Watson

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A range of alternative solvents have been evaluated within amidation reactions employing common coupling reagents with a view to identifying suitable replacements for dichloromethane and N,N-dimethylformamide
Original languageEnglish
Pages (from-to)596-600
Number of pages5
JournalGreen Chemistry
Issue number3
Early online date19 Dec 2012
Publication statusPublished - 2013


  • coupling reactions
  • coupling agents
  • solvents
  • amide

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