Fluorinated succinic acid derivatives from new refrigerants via ozonolysis of haloalkenes

Samantha J Brown, Stuart Corr, Jonathan Percy

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21 Citations (Scopus)


Fluoro- and di-fluoro allylic alcohols obtained from HFC-134a and HCFC-133a were transformed through [3,3]-sigmatropic rearrangements into 3-fluoro-4-halo-4-alkenoates with variable substitution at the 2- and 3-positions. Ozonolysis of the haloalkenes afforded the corresponding acyl halides which could be trapped with nucleophiles to afford fluorinated succinic acid derivatives in which the two carboxylic acid groups were differentiated.
Original languageEnglish
Pages (from-to)5269-5273
Number of pages5
JournalTetrahedron Letters
Issue number27
Publication statusPublished - 1 Jul 2000


  • allylic alcohols
  • ozonolysis
  • haloalkenes

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