Genetics and molecular biology: the role of nucleotide oligomerization domain-like genes in insulin resistance

D Rotondo, Jillian Davidson

Research output: Contribution to specialist publicationEditorial


Insulin resistance is linked to altered fat metabolism and elevated expression of inflammatory cytokines, particularly from fat tissue. This is turn is associated with obesity. It is proposed that NOD-like receptor expression may be responsible for inducing cytokine production from innate immune cells such as macrophages in fat tissue which in turn are linked to insulin resistance and obesity.
Original languageEnglish
Number of pages2
Specialist publicationCurrent Opinion in Lipidology
PublisherLippincott Williams and Wilkins
Publication statusPublished - 1 Oct 2012


  • insulin resistance
  • NOD-like receptors
  • inflammatory cytokines
  • macrophages
  • obesity
  • genetics
  • molecular biology
  • nucleotide oligomerization
  • domain-like genes

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