HFC-134a as a fluorinated building block: short syntheses of α-fluoroenones

J Marie Bainbridge, Stuart Corr, Masatomi Kanai, Jonathan Percy

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


1,1,1,2-Tetrafluoroethane (HFC-134a) has been transformed into a range of -fluoroenones via a direct route. Dehydrofluorination/metallation allowed trifluorovinylsilanes to be prepared; these could be converted in situ, or isolated and treated further, with alkyllithium reagents to give difluorovinylsilanes. Fluoride-catalysed addition to aldehydes followed by acidic work-up allowed the isolation of a range of -fluoroenones in two- or three-pots.
Original languageEnglish
Pages (from-to)971–974
Number of pages4
JournalTetrahedron Letters
Issue number6
Publication statusPublished - 5 Feb 2000


  • fluoroenones
  • aldehydes
  • trifluorovinylsilanes

Cite this