Hospital usage of TOXBASE in Great Britain: temporal trends in accesses 2008 to 2015

K Pyper, M Eddleston, DN Bateman, D Lupton, S Bradberry, E Sandilands, SHL Thomas, JP Thompson, C Robertson

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Aim: Examining temporal trends in accesses to the UK's National Poison Information Service's TOXBASE database in Britain.
Methods: Generalised additive models were used to examine trends in daily numbers of accesses to TOXBASE from British emergency departments between January 2008 and December 2015. Day-of-the-week, seasonality and long term trends were analysed at national and regional levels (Wales, Scotland and the 9 English Government Office Regions).
Results: The long-term trend in daily accesses increases from 2.8 (95% CI:2.6, 3.0) per user on 1st January 2008 to 4.6 (95% CI:4.3, 4.9) on 31st December 2015, with small but significant differences in population-corrected accesses by region (p<0.001). There are statistically significant seasonal and day of the week patterns (p<0.001) across all regions. Accesses are 18 % (95% CI:14%, 22%) higher in summer than in January and at the weekend compared to weekdays in all regions; there is a 7.5% (95% CI:6.1%, 8.9%) increase between Friday and Sunday.
Conclusions: There are consistent in-year patterns in access to TOXBASE indicating potential seasonal patterns in poisonings in Britain, with location-dependant rates of usage. This novel descriptive work lays the basis for future work on the interaction of TOXBASE use with emergency admission of patients into hospital.
Original languageEnglish
Pages (from-to)1207-1214
Number of pages8
JournalHuman and Experimental Toxicology
Issue number11
Early online date20 Feb 2018
Publication statusPublished - 1 Nov 2018


  • poisons information
  • epidemiology
  • time trends
  • regional variation
  • seasonality

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