In vitro variability in propofol absorption by different membrane oxygenators

S. Hickey, I. Quasim, J.D. Gaylor

    Research output: Contribution to conferenceOther


    Meeting abstract focusing on the sequestration of drugs, such as fentanyl [1,2], thiopental, nitroglycerine and propofol [3] in the extracorporeal circuit in vitro. This phenomenon can change the pharmacokinetic behaviour of drugs during cardiopulmonary bypass, thus potentially leading to problems in achieving adequate dosing regimens. The aim of this in vitro laboratory study was to compare the binding of propofol to different oxygenator membranes, and to examine the effects of the type of prime solution and temperature on the rate of binding. The SM-35 membrane bound significantly more propofol than the membranes from the CML and the SAFE II. Binding of propofol in diluted blood was significantly less than in crystalloid solution. Temperature had little effect on propofol binding in either prime solution type.
    Original languageEnglish
    Number of pages1
    Publication statusPublished - 2001
    Event18th Spring Meeting of the Association of Cardiothoracic Anaesthetists - Cambridge, United Kingdom
    Duration: 22 Jun 2001 → …


    Conference18th Spring Meeting of the Association of Cardiothoracic Anaesthetists
    Country/TerritoryUnited Kingdom
    Period22/06/01 → …


    • in vitro variability
    • drugs
    • bioscience
    • physiology
    • bioengineering

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