Isolation and structure elucidation of ardisenone: a new, cytotoxic alkenylphenol from Ardisia iwahigensis

F D Horgen, H Guinaudeau, J M Pezzuto, D D Soejarto, N R Farnsworth, F Agcaoili, G de los Reyes, R A Edrada, Ruangelie Edrada-Ebel

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26 Citations (Scopus)


A methanol extract of leaves and twigs from Ardisia iwahigensis demonstrated toxicity toward brine shrimp as well as LNCaP, ZR-75-1, and Lu1 human cancer cells in culture. A novel alkenylphenol, (Z)-1,16-bis(3-hydroxy-5-methoxyphenyl)-10-hexadecene-1,15-dione (ardisenone) (1), was isolated from the extract by bioassay-directed fractionation. This compound demonstrated moderate cytotoxicity against BC1, Lu1, Col2, KB, KB-V1, and LNCaP cell lines.

Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalJournal of Natural Products
Issue number5
Early online date22 May 1997
Publication statusPublished - May 1997


  • animals
  • anisoles
  • antineoplastic agents, phytogenic
  • artemia
  • drug screening assays, antitumor
  • humans
  • magnetic resonance spectroscopy
  • plant extracts
  • plants, Medicinal
  • spectrophotometry, infrared
  • tumor cells, cultured

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