Isomorphous template induced crystallisation: a robust method for the targeted crystallisation of computationally predicted metastable polymorphs

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A new method of inducing the crystallisation of metastable polymorphs by isomorphous templating has been developed and used to reproduce the crystallisation of CBZ-V on the surface of DHC-II. Studies of the growth of CBZ-V on DHC-II single crystals show crystals growing laterally and vertically on DHC-II surfaces without any significant face selectivity. The generality of this computationally inspired crystallisation approach is demonstrated by producing the first crystals of an entirely new polymorph of cyheptamide, which is isomorphous to both DHC-II and CBZ-V.
Original languageEnglish
Pages (from-to)7384-7386
Number of pages4
JournalChemical Communications
Issue number46
Early online date5 May 2016
Publication statusPublished - 11 Jun 2016


  • crystallisation
  • growing crystals
  • polymorphs

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