Local design principles of mammalian cortical networks

Shuzo Sakata, Yusuke Komatsu, Tetsuo Yamamori

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

To understand global and local design principles of mammalian cerebral cortical networks, we applied network-theoretical approaches to connectivity data from macaque and cat cortical networks. We first confirmed "small-world" properties and searched for the evidence of hierarchical modularity. To elucidate their local design principles, we then compared these cortical networks, based on the significance profile (SP) of network motifs in the real network compared to randomized networks. We found that SPs of different mammalian cortical networks are highly conserved and robust, suggesting constraints of neocortical development and evolution.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalNeuroscience Research
Volume51
Issue number3
Early online date23 Dec 2004
DOIs
Publication statusPublished - 31 Mar 2005

Keywords

  • cortical organization
  • feed-forward
  • feedback
  • graph theory
  • network theory
  • neuroinformatics
  • scale-free topology
  • small-world network

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