TY - JOUR

T1 - Model reduction of cell signal transduction networks via hybrid inference method

AU - Jia, J.F.

AU - Liu, T.Y.

AU - Yue, H.

AU - Wang, H.

PY - 2008

Y1 - 2008

N2 - The mathematical model of cell signal transduction networks is highly nonlinear and complex, which involves a large number of variables and kinetics parameters. How to effectively develop the reduced-order model is a major problem for analyzing complex systems. In this work, a model reduction strategy via hybrid inference method is proposed for complex signal transducion networks. This approach synthesizes metabolic control analysis, sensitivity analysis, principal component analysis, and flux analysis to reduce the dimensions of the model and to decrease the number of the biological reactions. Using NF-κB signaling pathway as an example, the detailed model consists of 24 ordinary differential equations and 64 parameters. According to the model reduction strategy, the reduced-order model is composed of 17 ordinary differential equations, one algebraic equation, and 52 parameters. The simulation results demonstrate that the reduced-order model quantitatively predicts the dynamic characteristics of the system output, which are much the same as that of the detailed model. Therefore, the model reduction strategy provides guidance for the analysis and design of complex cell networks. It is more effective and more straightforward to estimate the unknown parameters by means of the reduced-order model.

AB - The mathematical model of cell signal transduction networks is highly nonlinear and complex, which involves a large number of variables and kinetics parameters. How to effectively develop the reduced-order model is a major problem for analyzing complex systems. In this work, a model reduction strategy via hybrid inference method is proposed for complex signal transducion networks. This approach synthesizes metabolic control analysis, sensitivity analysis, principal component analysis, and flux analysis to reduce the dimensions of the model and to decrease the number of the biological reactions. Using NF-κB signaling pathway as an example, the detailed model consists of 24 ordinary differential equations and 64 parameters. According to the model reduction strategy, the reduced-order model is composed of 17 ordinary differential equations, one algebraic equation, and 52 parameters. The simulation results demonstrate that the reduced-order model quantitatively predicts the dynamic characteristics of the system output, which are much the same as that of the detailed model. Therefore, the model reduction strategy provides guidance for the analysis and design of complex cell networks. It is more effective and more straightforward to estimate the unknown parameters by means of the reduced-order model.

KW - cell signalling transduction networks

KW - model reduction

KW - hybrid inference method

KW - systems biology

UR - http://journal.gucas.ac.cn:8080/Jweb_yjsyxb/EN/abstract/abstract10846.shtml

UR - http://www.nt.ntnu.no/users/skoge/prost/proceedings/ifac2008/data/papers/2496.pdf

M3 - Article

VL - 25

SP - 355

EP - 366

JO - Journal of the Graduate School of the Chinese Academy of Sciences

JF - Journal of the Graduate School of the Chinese Academy of Sciences

SN - 1000-2952

IS - 3

ER -