Multi-parameter computational model of flow mediated dilation with fluid-structure interaction coupled with lumped parameter approaches

George Hyde-Linaker, Richard Anthony Black, Vittoria Flamini, Asimina Kazakidi

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Flow-mediated dilation (FMD) is a valuable non-invasive clinical assessment of endothelial dysfunction, a key indicator of atherosclerosis. The progression of atherosclerosis from paediatric ages can lead to the manifestation of cardiovascular diseases (CVDs) in later life. Hence, early lesion detection in younger years using FMD will heavily support timely disease assessment and treatment. In FMD, the diameter of the brachial artery is measured ultrasonically before, during, and after the inflation of a cuff applied to the lower arm of a subject. The cuff is placed distal to the ultrasound probe to capture predominantly endothelium-dependent vasodilation [1].The process induces a period of reactive hyperaemia, causing the brachial artery to vasodilate, due to an increase in shear stress that results in release of nitric oxide. The brachial artery ‘speak dilation is used for calculating the percentage difference between peak and baseline diameter (FMD percentage).Modelling FMD computationally offers a non-invasive assessment of vascular health and haemodynamic parameters.
Original languageEnglish
Number of pages1
Publication statusAccepted/In press - 28 Feb 2020
Event14th World Congress in Computational Mechanics - Paris, France
Duration: 19 Jul 202024 Jul 2020


Conference14th World Congress in Computational Mechanics


  • flow mediated dilation
  • fluid structure interaction
  • CFD
  • lumped parameters

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