New avenues for drug delivery in Leishmania: using treatment of visceral leishmaniasis with amphotericin B as an exemplar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this review the benefits of using a drug delivery system (DDS) to improve therapeutic outcome will be discussed using treatment of visceral leishmaniasis with amphotericin B (AMB), a poorly water soluble drug, as an exemplar. Progress in producing AMB formulations that can be given by intravenous, oral and pulmonary routes of administration is discussed.
Original languageEnglish
Title of host publicationDrug Discovery in Leishmaniasis
EditorsLuis Rivas, Carmen Gil
Place of PublicationCroydon
PublisherRoyal Society of Chemistry
Chapter11
Pages224 - 234
Number of pages11
ISBN (Electronic)9781788012584
ISBN (Print)9781782628897
Publication statusPublished - 1 Nov 2017

Keywords

  • Leishmania
  • drug discovery
  • drug delivery system
  • therapeutic outcomes
  • visceral leishmaniasis
  • intravenous administration
  • oral administration
  • pulmonary administration

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