Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes

J.A. Parkinson, P. Muller, B. Shroder, N.A. Kratochwil, R.A. Coxall, A. Parkin, S. Parsons, P.J. Sadler

Research output: Contribution to journalArticlepeer-review

109 Citations (Scopus)

Abstract

Visible light irradiation of inert [PtIV(diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N2, and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells.
Original languageEnglish
Pages (from-to)335-339
Number of pages5
JournalAngewandte Chemie
Volume42
Issue number3
DOIs
Publication statusPublished - 2003

Keywords

  • photoreactions
  • novel platinum (IV) azide complexes
  • cancer cells
  • irradiation

Fingerprint

Dive into the research topics of 'Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes'. Together they form a unique fingerprint.

Cite this