Optimization of the geometry and porosity of microelectrode arrays for sensor design

Mairi E. Sandison, Natalie Anicet, Andrew Glidle, Jonathan M. Cooper

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77 Citations (Scopus)


This paper describes the systematic investigation of a range of microelectrode arrays with varying dimensions fabricated by standard photolithographic and reactive-ion etching techniques. As expected from theory, the electrochemical behavior of microelectrode arrays with a constant individual diameter varied strongly with center-to-center spacing, the larger the spacing the more sigmoidal the recorded voltammogram. Furthermore, the behavior of arrays with a constant relative center-to-center spacing is shown to vary with individual electrode diameter, the arrays with the smallest electrodes producing strongly peaked voltammograms. Peak current densities and signal-to-noise ratios were also obtained for a variety of array geometries, and the use of electrodeposited platinum black electrodes was investigated. To demonstrate one advantage of using a loosely packed microelectrode array in electroanalysis, a ferrocene-mediated enzyme-linked assay involving the biocatalytic reduction of H2O2 was investigated. Results showed an improved temporal response, with current-time transients reaching a steady-state response more quickly using arrays with increased center-center spacings.

Original languageEnglish
Pages (from-to)5717-5725
Number of pages9
JournalAnalytical Chemistry
Issue number22
Early online date16 Oct 2002
Publication statusPublished - 15 Nov 2002


  • biosensing techniques
  • electrochemistry
  • enzyme-linked immunosorbent assay
  • indicators and reagents
  • microcomputers
  • microelectrodes
  • nanotechnology

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