Putrescine bisamides from Aglaia gigantea

Tu Ngoc Duong, RuAngelie Edrada, Rainer Ebel, Victor Wray, Walter Frank, Anh Tuan Duong, Wen Han Lin, Peter Proksch, Ruangelie Edrada-Ebel

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18 Citations (Scopus)


Phytochemical analysis of the leaves of Aglaia gigantea collected in Vietnam yielded three cinnamoyl putrescine bisamide derivatives, which included the known compound dasyclamide ( 1), as well as two new natural products, gigantamide A ( 2) and grandiamide D ( 3). In this study, the structure of dasyclamide ( 1) was confirmed by X-ray crystallography. The structures of the two new alkaloids, gigantamide A ( 2) and grandiamide D ( 3), were elucidated through extensive 1D and 2D NMR spectroscopy and analysis of their mass spectrometric (ESIMS, HRQTOFMS) data. The absolute configuration of grandiamide D ( 3) was determined via Mosher ester derivatization.

Original languageEnglish
Pages (from-to)1640-1643
Number of pages4
JournalJournal of Natural Products
Issue number10
Publication statusPublished - Oct 2007


  • aglaia
  • crystallography, X-Ray
  • molecular conformation
  • molecular structure
  • nuclear magnetic resonance, Biomolecular
  • plant leaves
  • plants, Medicinal
  • putrescine
  • Vietnam

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