Rapid prototyped microvessel flow phantom for controlled investigation of ultrasound-mediated targeted drug delivery

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Abstract

The ability to undertake controlled and accurate investigation of the complex features that determine microvasculature-fluid systems is essential in our progress towards successful clinical exploitation of ultrasound mediated targeted drug delivery (UmTDD). We present an engineered platform to enable accurate understanding of the microvascular flow characteristics capable of influencing UmTDD. We develop novel 3D-printed flow phantoms, accurately replicating real microvascular structures, and a new approach to investigating UmTDD phenomena that places microbubble-microvessel interactions at the heart of the problem. Our aim is to establish a robust, lab-based platform for controlled and systematic investigation of microvessel architectures as key determinants in UmTDD efficiency.

Original languageEnglish
Title of host publication2019 IEEE International Ultrasonics Symposium, IUS 2019
Place of PublicationPiscataway, N.J.
Pages2390-2393
Number of pages4
ISBN (Electronic)9781728145969
DOIs
Publication statusPublished - 6 Dec 2019
Event2019 IEEE International Ultrasonics Symposium: IEEE UFFC - SECC, Glasgow, United Kingdom
Duration: 6 Oct 20199 Oct 2019
https://attend.ieee.org/ius-2019/

Publication series

NameIEEE International Ultrasonics Symposium, IUS
Volume2019-October
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2019 IEEE International Ultrasonics Symposium
Abbreviated titleIUS 2019
Country/TerritoryUnited Kingdom
CityGlasgow
Period6/10/199/10/19
Internet address

Keywords

  • 3D-Printing
  • microCT
  • microvasculature
  • phantom
  • ultrasound-mediated targeted drug delivery

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