Strategy and tactics for hERG optimizations

Craig Jamieson; Elizabeth M. Moir; Zoran Rankovic; Grant. Wishart

doi:10.1002/9783527621460.ch18

Strategy and tactics for hERG optimizations

Craig Jamieson, Elizabeth M. Moir, Zoran Rankovic, Grant. Wishart

Pure And Applied Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

A review on the approaches used to circumvent activity at human ether-a-go-go related gene (hERG), identified through an extensive survey of the medicinal chem. literature until the end of 2006. [on SciFinder(R)]

Original language	English
Title of host publication	Antitargets
Subtitle of host publication	Prediction and Prevention of Drug Side Effects
Editors	Roy J. Vaz, Thomas Klabunde
Place of Publication	Weinheim, Germany
Pages	423-455
Number of pages	33
Volume	38
DOIs	https://doi.org/10.1002/9783527621460.ch18
Publication status	Published - Jan 2008

Publication series

Name	Methods and Principles in Medicinal Chemistry
Publisher	Wiley

Keywords

antitargets
case studies
drug optimization
hERG optimizations
strategies to diminish hERG
structural modifications
formation of zwitterions
control of log P
attenuation of pKa

Access to Document

10.1002/9783527621460.ch18

Cite this

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title = "Strategy and tactics for hERG optimizations",

abstract = "A review on the approaches used to circumvent activity at human ether-a-go-go related gene (hERG), identified through an extensive survey of the medicinal chem. literature until the end of 2006. [on SciFinder(R)]",

keywords = "antitargets, case studies, drug optimization, hERG optimizations, strategies to diminish hERG, structural modifications, formation of zwitterions, control of log P, attenuation of pKa",

author = "Craig Jamieson and Moir, {Elizabeth M.} and Zoran Rankovic and Grant. Wishart",

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Strategy and tactics for hERG optimizations. / Jamieson, Craig; Moir, Elizabeth M.; Rankovic, Zoran; Wishart, Grant.

Antitargets: Prediction and Prevention of Drug Side Effects. ed. / Roy J. Vaz; Thomas Klabunde. Vol. 38 Weinheim, Germany, 2008. p. 423-455 (Methods and Principles in Medicinal Chemistry).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

TY - CHAP

T1 - Strategy and tactics for hERG optimizations

AU - Jamieson, Craig

AU - Moir, Elizabeth M.

AU - Rankovic, Zoran

AU - Wishart, Grant.

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KW - antitargets

KW - case studies

KW - drug optimization

KW - hERG optimizations

KW - strategies to diminish hERG

KW - structural modifications

KW - formation of zwitterions

KW - control of log P

KW - attenuation of pKa

U2 - 10.1002/9783527621460.ch18

DO - 10.1002/9783527621460.ch18

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SN - 978-3-527-31821-6

VL - 38

T3 - Methods and Principles in Medicinal Chemistry

SP - 423

EP - 455

BT - Antitargets

A2 - Vaz, Roy J.

A2 - Klabunde, Thomas

CY - Weinheim, Germany

ER -