Surface-enhanced Raman spectroscopy for in vivo biosensing

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Surface-enhanced Raman scattering (SERS) is of interest for biomedical analysis and imaging because of its sensitivity, specificity and multiplexing capabilities. The successful application of SERS for in vivo biosensing requires probes to be biocompatible and procedures to be minimally invasive, challenges that have respectively been met by developing new nanoprobes and instrumentation. This Review presents recent developments in these areas, describing case studies in which sensors have been implemented, as well as outlining shortcomings that must be addressed before SERS sees clinical use.

Original languageEnglish
Article number0060
Number of pages19
JournalNature Reviews Chemistry
Early online date9 Aug 2017
Publication statusE-pub ahead of print - 9 Aug 2017


  • surface enhanced Raman scattering
  • biosensing
  • in vitro

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