Synthesis of an allylic gem-difluoromethylene building block via radical-mediated difluorocyclopropane ring opening

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We report an optimised and highly efficient synthetic route towards a valuable functionalised fluorinated building block. The key-steps include difluorocyclopropanation of a disubstituted alkene with a suitable difluorocarbene precursor, and a radical-induced cyclopropane ring-opening, operating via an iodide atom transfer reaction.
Original languageEnglish
Article number153344
Number of pages4
JournalTetrahedron Letters
Early online date25 Aug 2021
Publication statusPublished - 28 Sep 2021


  • fluorinated building blocks
  • difluorocyclopropanation
  • difluorocyclopropane ring opening

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