Templated deprotonative metalation of polyaryl systems: facile access to simple, previously inaccessible multi-iodoarenes

Antonio J. Martínez-Martínez, Stephen Justice, Ben J. Fleming, Alan R. Kennedy, Iain D. H. Oswald, Charles T. O'Hara

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The development of new methodologies to affect non-ortho functionalization of arenes has emerged as a globally important arena for research, which is key to both fundamental studies and applied technologies. Here, a range of simple arene feedstocks (namely, biphenyl, meta-terphenyl, para-terphenyl, 1,3,5-triphenylbenzene and biphenylene) are transformed to hitherto unobtainable multi-iodoarenes via a s-block metal sodium magnesiate templated deprotonative approach. These iodoarenes have potential to be used in a whole host of high impact transformations, as precursors to key materials in the pharmaceutical, molecular electronic and nanomaterials industries. Proving the concept, we have transformed biphenyl to 3,5-bis(N-carbazolyl)-1,1’-biphenyl, a novel isomer of 4,4’-bis(N-carbazolyl)-1,1’-biphenyl (CPB) which is currently widely employed as a host material for organic light-emitting diodes, OLEDs.
Original languageEnglish
Article numbere1700832
Number of pages8
JournalScience Advances
Issue number6
Publication statusPublished - 30 Jun 2017


  • organic molecules
  • iodoarenes
  • C-H bond-breaking

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