The effect of cell ingrowth on the mechanical behaviour of anchored collagen gels

Grahame Busby; Philip Riches; Mary Grant; Simon MacKay

doi:10.5301/ijao.5000244

The effect of cell ingrowth on the mechanical behaviour of anchored collagen gels

Grahame Busby, Philip Riches, Mary Grant, Simon MacKay

Research output: Contribution to journal › Meeting abstract › peer-review

Abstract

Collagen gels are often used in studies of cell-matrix interactions and as scaffolds for tissue engineering. However, the effect of cell proliferation on their bulk mechanical properties is still poorly understood. We recently published a method for extracting meaningful mechanical properties from collagen gels of > 99.5% water, using confined compression and biphasic theory (J Biomech 46 (2013) 837). In the present study we used this technique to investigate the effects of cell ingrowth on the transient mechanical behaviour of highly hydrated collagen gels.

Original language	English
Article number	O106
Pages (from-to)	567
Journal	International Journal of Artificial Organs
Volume	36
Issue number	8
DOIs	https://doi.org/10.5301/ijao.5000244
Publication status	Published - Aug 2013
Event	XL Congress of the European Society for Artificial Organs - Glasgow, United Kingdom Duration: 11 Sep 2013 → 14 Sep 2013

Keywords

cell ingrowth
collagen gels
cell-matrix interactions
tissue engineering scaffolds
tissue engineering

Access to Document

10.5301/ijao.5000244

Cite this

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title = "The effect of cell ingrowth on the mechanical behaviour of anchored collagen gels",

abstract = "Collagen gels are often used in studies of cell-matrix interactions and as scaffolds for tissue engineering. However, the effect of cell proliferation on their bulk mechanical properties is still poorly understood. We recently published a method for extracting meaningful mechanical properties from collagen gels of > 99.5% water, using confined compression and biphasic theory (J Biomech 46 (2013) 837). In the present study we used this technique to investigate the effects of cell ingrowth on the transient mechanical behaviour of highly hydrated collagen gels.",

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T1 - The effect of cell ingrowth on the mechanical behaviour of anchored collagen gels

AU - Busby, Grahame

AU - Riches, Philip

AU - Grant, Mary

AU - MacKay, Simon

PY - 2013/8

Y1 - 2013/8

N2 - Collagen gels are often used in studies of cell-matrix interactions and as scaffolds for tissue engineering. However, the effect of cell proliferation on their bulk mechanical properties is still poorly understood. We recently published a method for extracting meaningful mechanical properties from collagen gels of > 99.5% water, using confined compression and biphasic theory (J Biomech 46 (2013) 837). In the present study we used this technique to investigate the effects of cell ingrowth on the transient mechanical behaviour of highly hydrated collagen gels.

AB - Collagen gels are often used in studies of cell-matrix interactions and as scaffolds for tissue engineering. However, the effect of cell proliferation on their bulk mechanical properties is still poorly understood. We recently published a method for extracting meaningful mechanical properties from collagen gels of > 99.5% water, using confined compression and biphasic theory (J Biomech 46 (2013) 837). In the present study we used this technique to investigate the effects of cell ingrowth on the transient mechanical behaviour of highly hydrated collagen gels.

KW - cell ingrowth

KW - collagen gels

KW - cell-matrix interactions

KW - tissue engineering scaffolds

KW - tissue engineering

U2 - 10.5301/ijao.5000244

DO - 10.5301/ijao.5000244

M3 - Meeting abstract

VL - 36

SP - 567

JO - International Journal of Artificial Organs

JF - International Journal of Artificial Organs

SN - 0391-3988

IS - 8

M1 - O106

T2 - XL Congress of the European Society for Artificial Organs

Y2 - 11 September 2013 through 14 September 2013

ER -