The risk of developing a second primary cancer in melanoma patients: a comprehensive review of the literature and meta-analysis

Saverio Caini, Mathieu Boniol, Edoardo Botteri, Giulio Tosti, Barbara Bazolli, William Russell-Edu, Francesco Giusti, Alessandro Testori, Sara Gandini

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40 Citations (Scopus)


The number of cutaneous melanoma survivors has been increasing for years due to improvements in early diagnosis and subsequent prolonged survival. These patients are at increased risk of developing a second melanoma and a second primary malignancy (SPM) at other sites as well. We performed a review of scientific literature and meta-analysis to evaluate the risk of developing a SPM (other than melanoma) among melanoma patients. Twenty-three independent papers and over 350,000 melanoma patients were included. Risk of cancer among melanoma survivors was increased overall (1.57, 95% CI 1.29-1.90) and at several sites: bone (2.09, 95% CI 1.08-4.05), non-melanoma skin cancer (4.01, 95% CI 1.81-8.87), soft tissue (6.80, 95% CI 1.29-35.98), colon-rectum (1.12, 95% CI 1.00-1.25), female breast (1.14, 95% CI 1.07-1.22), kidney (1.34, 95% CI 1.23-1.45), prostate (1.25, 95% CI 1.13-1.37) and non-Hodgkin lymphoma (1.37, 95% CI 1.22-1.54). The overall risk of SPM showed a tendency to decrease as the time from melanoma diagnosis lengthened. Most of our findings may be explained by the tendency of some exposures, which are risk factors for different tumors, to occur simultaneously in the same individuals. These results suggest primary and secondary cancer prevention counselling for melanoma survivors.

Original languageEnglish
Pages (from-to)3-9
Number of pages7
JournalJournal of Dermatological Science
Issue number1
Early online date5 Mar 2014
Publication statusPublished - 1 Jul 2014


  • female
  • humans
  • male
  • melanoma
  • neoplasms, second primary
  • risk assessment
  • risk factors
  • skin neoplasms
  • survivors
  • time factors

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