The toxicity of orthopaedic biomaterials chromium and nickel in rat hepatocytes

M. Gunaratnam, M.H. Grant

    Research output: Chapter in Book/Report/Conference proceedingChapter


    The toxicity of nickel, chromium (III) and (VI), vanadium and aluminium was compared in an immortalized neonatal rat osteoblast cell line using the MTT assay and a novel index of cytoxicity, alkaline phosphatase (ALP) activity.
    Original languageEnglish
    Title of host publicationTransactions of the 28th Annual Meeting of the Society for Biomaterials
    Publication statusPublished - 2002


    • cytotoxicity
    • metals
    • immortalized rat osteoblasts
    • alkaline phosphatase activity

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