Toxoplasma gondii tachyzoite-bradyzoite interconversion

Russell E Lyons, Rima McLeod, Craig W Roberts

Research output: Contribution to journalArticlepeer-review

144 Citations (Scopus)

Abstract

During infection in the intermediate host, Toxoplasma gondii undergoes stage conversion between the rapidly dividing tachyzoite that is responsible for acute toxoplasmosis and the slowly replicating, encysted bradyzoite stage. This process of tachyzoite-bradyzoite interconversion is central to the pathogenesis and longevity of infection. Recent research has identified several stage-specific genes and proteins. However, despite recent advances in the understanding of Toxoplasma cell biology, more research is necessary to elucidate the complex events occurring during tachyzoite-bradyzoite interconversion. Here, a brief summary of this process is provided and a new method to characterize gene expression during interconversion is introduced.

Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalTrends in Parasitology
Volume18
Issue number5
Early online date24 Apr 2002
DOIs
Publication statusPublished - May 2002

Keywords

  • tissue cyst formation
  • molecular-cloning
  • stage converstion
  • differential expression
  • targeted disruption
  • gene
  • antigen
  • surface
  • induction
  • enzymes

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