Two-dimensional infrared spectroscopy: an emerging analytical tool?

Robby Fritzsch, Samantha Hume, Lucy Minnes, Matthew J. Baker, Glenn A. Burley, Neil T. Hunt

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
8 Downloads (Pure)


Ultrafast two-dimensional infrared (2D-IR) spectroscopy has provided valuable insights into biomolecular structure and dynamics, but recent progress in laser technology and data analysis methods have demonstrated the potential for high throughput 2D-IR measurements and analytical applications. Using 2D-IR as an analytical tool requires a different approach to data collection and analysis compared to pure research applications however and, in this review, we highlight progress towards usage of 2D-IR spectroscopy in areas relevant to biomedical, pharmaceutical and analytical molecular science. We summarise the technical and methodological advances made to date and discuss the challenges that still face 2D-IR spectroscopy as it attempts to transition from the state-of-the-art laser laboratory to the standard suite of analytical tools.
Original languageEnglish
Pages (from-to)2014-2024
Number of pages11
Issue number6
Early online date10 Feb 2020
Publication statusPublished - 21 Mar 2020


  • ultrafast 2D-IR spectroscopy
  • infrared spectroscopy
  • vibrational dynamics
  • analytical tools

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