UV-induced 1,3,4-oxadiazole formation from 5-substituted tetrazoles and carboxylic acids in flow

Luke Green; Keith Livingstone; Sophie Bertrand; Simon Peace; Craig Jamieson

doi:10.1002/chem.202002896

UV-induced 1,3,4-oxadiazole formation from 5-substituted tetrazoles and carboxylic acids in flow

Luke Green, Keith Livingstone, Sophie Bertrand, Simon Peace, Craig Jamieson

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

38 Downloads (Pure)

Abstract

A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.

Original language	English
Pages (from-to)	14866-14870
Number of pages	5
Journal	Chemistry - A European Journal
Volume	26
Issue number	65
Early online date	12 Aug 2020
DOIs	https://doi.org/10.1002/chem.202002896
Publication status	Published - 20 Nov 2020

Keywords

UV-B activated flow
1,3,4-oxadiazoles
carboxylic acids
5-substituted tetrazoles

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10.1002/chem.202002896Licence: CC BY 4.0

Green-etal-CEJ-2020-UV-induced-1-3-4-oxadiazole-formation-from-5-substituted-tetrazolesFinal published version, 1.16 MBLicence: CC BY 4.0

1 Active

Accelerated Discovery and Development of New Medicines: Prosperity Partnership for a Healthier Nation
Kerr, W., Brown, C., Florence, A., Jamieson, C., Johnston, B., Murphy, J., Palmer, D. & Tomkinson, N.
EPSRC (Engineering and Physical Sciences Research Council)
1/01/19 → 30/09/24
Project: Research

Cite this

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title = "UV-induced 1,3,4-oxadiazole formation from 5-substituted tetrazoles and carboxylic acids in flow",

abstract = "A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.",

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T1 - UV-induced 1,3,4-oxadiazole formation from 5-substituted tetrazoles and carboxylic acids in flow

AU - Green, Luke

AU - Livingstone, Keith

AU - Bertrand, Sophie

AU - Peace, Simon

AU - Jamieson, Craig

PY - 2020/11/20

Y1 - 2020/11/20

N2 - A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.

AB - A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.

KW - UV-B activated flow

KW - 1,3,4-oxadiazoles

KW - carboxylic acids

KW - 5-substituted tetrazoles

U2 - 10.1002/chem.202002896

DO - 10.1002/chem.202002896

M3 - Article

VL - 26

SP - 14866

EP - 14870

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 65

ER -

UV-induced 1,3,4-oxadiazole formation from 5-substituted tetrazoles and carboxylic acids in flow

Abstract

Keywords

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Projects

Accelerated Discovery and Development of New Medicines: Prosperity Partnership for a Healthier Nation

Cite this